IHHP Article: A study of the anti-lipid and anti-hypertensive effects of Achillea wilhelmsii in a double blind clinical trial
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A study of the anti-lipid and anti-hypertensive effects of Achillea wilhelmsii in a double blind clinical trial

Sedighe Asgari, Gholam Ali Naderi, Masoumeh Sadeghi, Babak Sabet, Noushin Mohammadifard, Nazila Askari

Abstract
Achillea wilhelmsii C. Koch (Asteraceae) is widely found in different parts of Iran. This plant is laden with flavonoids and sesquiterpene lactones which are effective on blood lipids and hypertension. This is a double-blind placebo clinical trial to study the anti-hyperlipidemic and antihypertensive effects of Achillea drop.
One-hundred twenty men and women aged between 40 and 60 years were randomly selected and divided into two distinct groups of moderate hyperlipidemic and primary hypertensive subjects. They were treated either by the hydroalcoholic extract or placebo (15-20 drops) twice daily for more than 6 months. Blood pressure and serum lipids as total cholesterol (T. chol), triglyceride (TG), LDL cholesterol and HDL cholesterol were measured three times in the groups at two-month intervals. The mean and standard deviation of alternations in these variables were compared between groups receiving placebo and drug using t-student test. The results showed a significant decrease only in TG after two months, whereas decrease in TG, T. chol and LDL became significant after four months. HDL showed a significant increase after 6 months of intervention. Significant decrease was observed in diastolic and systolic blood pressures after 2 and 6 months, respectively (P<0.05).

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